Dual Systemic Tumor Targeting with Ligand-Directed Phage and Grp78 Promoter Induces Tumor Regression
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منابع مشابه
Therapeutic Discovery Dual Systemic Tumor Targeting with Ligand-Directed Phage and Grp78 Promoter Induces Tumor Regression
The tumor-specificGrp78promoter is overexpressed in aggressive tumors. Cancer patientswould benefit greatly from application of this promoter in gene therapy and molecular imaging; however, clinical benefit is limited by lack of strategies to target the systemic delivery of Grp78-driven transgenes to tumors. This study aims to assess the systemic efficacy of Grp78-guided expression of therapeut...
متن کاملDual systemic tumor targeting with ligand-directed phage and Grp78 promoter induces tumor regression.
The tumor-specific Grp78 promoter is overexpressed in aggressive tumors. Cancer patients would benefit greatly from application of this promoter in gene therapy and molecular imaging; however, clinical benefit is limited by lack of strategies to target the systemic delivery of Grp78-driven transgenes to tumors. This study aims to assess the systemic efficacy of Grp78-guided expression of therap...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2012
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-12-0587